Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Mar 2020

Southwell Derek G, Seifikar Helia, Malik Ruchi, Lavi Karen, Vogt Daniel, Rubenstein John L, Sohal Vikaas S

Abstract excerpt

Manipulations that enhance GABAergic inhibition have been associated with improved behavioral phenotypes in autism models, suggesting that autism may be treated by correcting underlying deficits of inhibition. Interneuron transplantation is a method for increasing recipient synaptic inhibition, and it has been considered a prospective therapy for conditions marked by deficient inhibition, including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Tissue Transplantation
Share to Exploratory Behavior

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fetal Tissue Transplantation

Share to GABAergic Neurons

Share to Interneurons

Share to Maze Learning

Share to Neural Inhibition

Share to Prefrontal Cortex

Source

Open in PubMed Open full text

Identifiers

PMID: 31988060
DOI: 10.1523/JNEUROSCI.1063-19.2019
PMCID: PMC7083289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition.PMID 31988060Read ↗

The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles.Semantic proximity Read ↗

Exploring the mechanisms underlying excitation/inhibition imbalance in human iPSC-derived models of ASD.Semantic proximity Read ↗

Inhibitory control of the excitatory/inhibitory balance in psychiatric disordersSemantic proximity Read ↗

Dysregulation of Neuropilin-2 Expression in Inhibitory Neurons Impairs Hippocampal Circuit Development and Enhances Risk for Autism-Related Behaviors and SeizuresSemantic proximity Read ↗

Dysregulation of Neuropilin-2 Expression in Inhibitory Neurons Impairs Hippocampal Circuit Development Leading to Autism-Epilepsy PhenotypeSemantic proximity Read ↗

Restoring interbrain prefrontal theta synchronization reverses social deficitsSemantic proximity Read ↗

Conditional Pten knockout in parvalbumin- or somatostatin-positive neurons sufficiently leads to autism-related behavioral phenotypes.Semantic proximity Read ↗

Changes in neural network homeostasis trigger neuropsychiatric symptoms.Semantic proximity Read ↗

Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypesSemantic proximity Read ↗

GABAergic cell loss in mice lacking autism-associated gene <i>Sema6A</i>Semantic proximity Read ↗

Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated <i>Scn2a</i> -deficiencySemantic proximity Read ↗

Altered excitatory transmission onto hippocampal interneurons in the IQSEC2 mouse model of X-linked neurodevelopmental disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.