Article
Altered excitatory transmission onto hippocampal interneurons in the IQSEC2 mouse model of X-linked neurodevelopmental disease.
Neurobiology of disease - 1 Apr 2020
Sah Megha, Shore Amy N, Petri Sabrina, Kanber Ayla, Yang Mu, Weston Matthew C, Frankel Wayne N
Abstract excerpt
Mutations in the X-linked gene IQSEC2 are associated with multiple cases of epilepsy, epileptic encephalopathy, intellectual disability and autism spectrum disorder, the mechanistic understanding and successful treatment of which remain a significant challenge in IQSEC2 and related neurodevelopmental genetic diseases. To investigate disease etiology, we studied behaviors and synaptic function in IQSEC2 deficient...
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