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Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated <i>Scn2a</i> -deficiency

2025-03-05

Abstract excerpt

<h4>ABSTRACT</h4> Social behavior is critical for survival and adaptation, which is profoundly disrupted in autism spectrum disorders (ASD). Social withdrawal due to information overload was often described in ASD, and it was suspected that increased basal noise, i.e., excessive background neuronal activities in the brain could be a disease mechanism. However, experimental test of this hypothesis is limited. Loss...

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Literature Corpus work
f12ec02e-7155-53dd-8e8c-f7df7d5690b3
DOI
10.1101/2025.03.04.641498
Open publication

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Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated <i>Scn2a</i> -deficiencyDOI 10.1101/2025.03.04.641498
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