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Molecular characteristics and in vitro susceptibility to bedaquiline of Mycobacterium tuberculosis isolates circulating in Shaanxi, China.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Oct 2020

Yang Jian, Pang Yu, Zhang Tianhua, Xian Xiaoping, Li Yan, Wang Rui, Wang Panting, Zhang Meng, Wang Junyang

Abstract excerpt

OBJECTIVE: The aim of this study was to investigate the molecular characteristics and in vitro susceptibility to bedaquiline of Mycobacterium tuberculosis (MTB) isolates from Shaanxi, China. METHODS: The minimum inhibitory concentration (MIC) of bedaquiline was determined using the microplate alamarBlue assay for 518 MTB isolates from Shaanxi. Isolates with MIC values of bedaquiline ≥0.12 μg/mL were sequenced for...

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PMID: 32738481
DOI: 10.1016/j.ijid.2020.07.044

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