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Spindle Poisons and Cell Fate: A Tale of Two Pathways

1 Apr 2011

Abstract excerpt

Spindle poisons, such as paclitaxel and vinblastine, exert their potent anti-neoplastic effects through activation of the spindle assembly checkpoint (SAC), thereby arresting cells in mitosis. Unfortunately, only certain cancers are susceptible to these drugs, and many patients fail to respond to treatment. We review the pathways that are triggered by spindle poisons and highlight recent studies that describe the...

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PMID: 21540474
DOI: 10.1124/mi.11.2.12

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