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Article

POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function

13 Apr 2012

Abstract excerpt

The germinal center (GC) is a unique histological structure found in peripheral lymphoid organs. GCs provide an important source of humoral immunity by generating high affinity antibodies against a pathogen. The GC response is tightly regulated during clonal expansion, immunoglobulin modification, and affinity maturation, whereas its deregulation has a detrimental effect on immune function, leading to development...

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PMID: 22500835
DOI: 10.1111/j.1600-065x.2012.01116.x

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