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Article

Anti-HIV-1 Activity of the Integrase Strand Transfer Inhibitor ACC017.

Viruses - 24 Dec 2025

Ma Meng-Di, Luo Rong-Hua, Li Chun-Yan, Huang Guan-Cheng, Long Xin-Yan, He Feng-Ying, Yang Liu-Meng, Fu He-Liang, Zheng Yong-Tang

Abstract excerpt

HIV-1 integrase strand transfer inhibitors (INSTIs) are pivotal to antiretroviral therapy. However, the emergence of drug-resistant mutations necessitates the development of new agents. Here, we present ACC017 as a novel INSTI candidate. ACC017 demonstrated potent activity against the laboratory-adapted HIV-1IIIB strain (EC50 = 0.59 nM; SI > 34,525) and maintained efficacy against a panel of drug-resistant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41600798
DOI: 10.3390/v18010033
PMCID: PMC12846677

Genes

SI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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