Article

Novel Wild Type and Mutate HIV-1 Protease Inhibitors Containing Heteroaryl Carboxamides in P2: Synthesis, Biological and ADME Evaluations

2023-05-16

Abstract excerpt

The Virus HIV-1 infection still represents a serious disease even if actually it is transformed in chronic pathology. Considering the crucial role of the enzyme Protease in life cycle of HIV many efforts have been made in the research of new organic compounds showing inhibitory activity. After development of several series of non peptidic inhibitors we report here the synthesis of novel simple HIV-Protease inhibit...

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Literature Corpus work: 94a3c04f-e290-53bc-87de-c45115354e2b
DOI: 10.20944/preprints202305.1103.v1

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