Article
Ex-vivo antiretroviral potency of newer integrase strand transfer inhibitors cabotegravir and bictegravir in HIV type 1 non-B subtypes.
AIDS (London, England) - 20 Feb 2018
Neogi Ujjwal, Singh Kamalendra, Aralaguppe Shambhu G, Rogers Leonard C, Njenda Duncan T, Sarafianos Stefan G, Hejdeman Bo, Sönnerborg Anders
Abstract excerpt
OBJECTIVE: To determine the antiretroviral activity of the integrase strand transfer inhibitors (INSTIs), raltegravir (RAL), elvitegravir (EVG), dolutegravir (DTG), cabotegravir (CAB) and bictegravir (BIC), against different subtypes as well as primary and acquired drug resistance mutations (DRMs) in a patient-cohort infected with diverse subtypes. DESIGN: Biochemical and virological drug sensitivity analyses...
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