Article
Detection of mitochondrial DNA variants at low level heteroplasmy in pediatric CNS and extra-CNS solid tumors with three different enrichment methods.
Mitochondrion - 1 Mar 2020
Kaneva Kristiyana, Merkurjev Daria, Ostrow Dejerianne, Ryutov Alex, Triska Petr, Stachelek Kevin, Cobrinik David, Biegel Jaclyn A, Gai Xiaowu
Abstract excerpt
The mitochondrial genome is small, 16.5 kb, and yet complex to study due to an abundance of mitochondria in any given cell or tissue. Mitochondrial DNA (mtDNA) mutations have been previously described in cancer, many of which were detected at low heteroplasmy. In this study we enriched the mitochondrial genome in primary pediatric tumors for detection of mtDNA variants. We completed mtDNA enrichment using...
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