Article
Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients.
Cell - 21 Apr 2016
Banchereau Romain, Hong Seunghee, Cantarel Brandi, Baldwin Nicole, Baisch Jeanine, Edens Michelle, Cepika Alma-Martina, Acs Peter, Turner Jacob, Anguiano Esperanza, Vinod Parvathi, Kahn Shaheen, Obermoser Gerlinde, Blankenship Derek, Wakeland Edward, Nassi Lorien, Gotte Alisa, Punaro Marilynn, Liu Yong-Jun, Banchereau Jacques, Rossello-Urgell Jose, Wright Tracey, Pascual Virginia
Abstract excerpt
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of tolerance to nucleic acids and highly diverse clinical manifestations. To assess its molecular heterogeneity, we longitudinally profiled the blood transcriptome of 158 pediatric patients. Using mixed models accounting for repeated measurements, demographics, treatment, disease activity (DA), and nephritis class, we confirmed a...
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