Article
Cryo-Electron Microscopy Structure of the αIIbβ3-Abciximab Complex.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2020
Nešić Dragana, Zhang Yixiao, Spasic Aleksandar, Li Jihong, Provasi Davide, Filizola Marta, Walz Thomas, Coller Barry S
Abstract excerpt
OBJECTIVE: The αIIbβ3 antagonist antiplatelet drug abciximab is the chimeric antigen-binding fragment comprising the variable regions of murine monoclonal antibody 7E3 and the constant domains of human IgG1 and light chain κ. Previous mutagenesis studies suggested that abciximab binds to the β3 C177-C184 specificity-determining loop (SDL) and Trp129 on the adjacent β1-α1 helix. These studies could not, however,...
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