Article
AlphaIIb's cytoplasmic domain is not required for ligand-induced clustering of integrin alphaIIbbeta3.
Biochimica et biophysica acta - 25 Jul 2001
Hantgan R R, Stahle M, Del Gaizo V, Adams M, Lasher T, Jerome W G, McKenzie M, Lyles D S
Abstract excerpt
The platelet integrin alphaIIbbeta3 exhibits bidirectional signaling, in that intracellular messengers enable adhesive macromolecules to bind to its ectodomain, while ligation promotes the association of cytoskeletal proteins with its cytoplasmic domains. In order to understand the linkage between these distant regions, we investigated the effects of receptor occupancy on the solution structure of both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.