Article
Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.
Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2018
Alam Amer, Küng Raphael, Kowal Julia, McLeod Robert A, Tremp Nina, Broude Eugenia V, Roninson Igor B, Stahlberg Henning, Locher Kaspar P
Abstract excerpt
The multidrug transporter ABCB1 (P-glycoprotein) is an ATP-binding cassette transporter that has a key role in protecting tissues from toxic insult and contributes to multidrug extrusion from cancer cells. Here, we report the near-atomic resolution cryo-EM structure of nucleotide-free ABCB1 trapped by an engineered disulfide cross-link between the nucleotide-binding domains (NBDs) and bound to the antigen-binding...
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