Article
Distinct roles for two RAD51-related genes in Trypanosoma brucei antigenic variation.
Nucleic acids research - 1 Jan 2005
Proudfoot Chris, McCulloch Richard
Abstract excerpt
In Trypanosoma brucei, DNA recombination is crucial in antigenic variation, a strategy for evading the mammalian host immune system found in a wide variety of pathogens. T.brucei has the capacity to encode >1000 antigenically distinct variant surface glycoproteins (VSGs). By ensuring that only one VSG is expressed on the cell surface at one time, and by periodically switching the VSG gene that is expressed,...
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