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Article

Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes.

Molecular oncology - 1 Oct 2012

Holm Karolina, Grabau Dorthe, Lövgren Kristina, Aradottir Steina, Gruvberger-Saal Sofia, Howlin Jillian, Saal Lao H, Ethier Stephen P, Bendahl Pär-Ola, Stål Olle, Malmström Per, Fernö Mårten, Rydén Lisa, Hegardt Cecilia, Borg Åke, Ringnér Markus

Abstract excerpt

Polycomb repressive complex 2 (PRC2) and its core member enhancer of zeste homolog 2 (EZH2) mediate the epigenetic gene silencing mark: trimethylation of lysine 27 on histone 3 (H3K27me3). H3K27me3 is characteristic of the chromatin at genes involved in developmental regulation in undifferentiated cells. Overexpression of EZH2 has been found in several cancer types such as breast, prostate, melanoma and bladder...

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Source

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Identifiers

PMID: 22766277
DOI: 10.1016/j.molonc.2012.06.002
PMCID: PMC5528390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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