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Article

Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes

1 Nov 2021

Abstract excerpt

Triple-negative breast cancer (TNBC) is a collection of biologically diverse cancers characterized by distinct transcriptional patterns, biology, and immune composition. TNBCs subtypes include two basal-like (BL1, BL2), a mesenchymal (M) and a luminal androgen receptor (LAR) subtype. Through a comprehensive analysis of mutation, copy number, transcriptomic, epigenetic, proteomic, and phospho-proteomic patterns we...

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PMID: 34725325
DOI: 10.1038/s41467-021-26502-6

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