Article

Epigenetic activation of CHST2 by promoter hypomethylation promotes progression of triple-negative breast cancer

2026-02-14

Abstract excerpt

Epigenetic dysregulation is a hallmark of triple-negative breast cancer (TNBC), yet the oncogenic relevance of specific epigenetically activated genes remains poorly defined. In this study, we demonstrate that carbohydrate sulfotransferase 2 (CHST2) is aberrantly upregulated in TNBC across multiple transcriptomic analyses as a consequence of promoter hypomethylation. Elevated CHST2 expression is associated with ag...

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Literature Corpus work: cf3f7f36-9d50-595a-8916-dd1564a762fa
DOI: 10.64898/2026.02.12.705678

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