Article
SPOP mutations increase PARP inhibitor sensitivity via CK2/PIAS1/SPOP axis in prostate cancer.
JCI insight - 22 Apr 2025
Zhang Hui, Kong Lili, Li Jinhui, Liu Zhihan, Zhao Yiting, Lv Xiuyi, Wu Liangpei, Chai Lin, You Hongjie, Jin Jiabei, Cao Xinyi, Zheng Zhong, Liu Yadong, Yan Zejun, Jin Xiaofeng
Abstract excerpt
It is well documented that impaired DNA damage repair (DDR) induces genomic instability that can efficiently increase the sensitivity of prostate cancer (PCa) cells to PARP inhibitors; however, the underlying mechanism remains elusive. Here, we found profound genomic instability in PCa cells with SPOP gene mutations and confirmed the sensitivity of SPOP-mutated PCa cells to olaparib-induced apoptosis....
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