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Article

ATM Serine/Threonine Kinase and its Role in Pancreatic Risk

17 Jan 2020

Abstract excerpt

Next-generation sequencing has led to the recent discovery of several novel pancreatic cancer susceptibility genes. These genes include ataxia telangiectasia mutated (ATM), a serine/threonine kinase that is an integral component of DNA repair. Pathogenic germline ATM variants are frequently identified in patients with pancreatic ductal adenocarcinoma (PDAC) with and without a family history of the disease. Loss...

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PMID: 31963441
DOI: 10.3390/genes11010108

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