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Article

ATM Dysfunction in Pancreatic Adenocarcinoma and Associated Therapeutic Implications.

Molecular cancer therapeutics - 1 Nov 2019

Armstrong Samantha A, Schultz Christopher W, Azimi-Sadjadi Ariana, Brody Jonathan R, Pishvaian Michael J

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal solid malignancies with very few therapeutic options to treat advanced or metastatic disease. The utilization of genomic sequencing has identified therapeutically relevant alterations in approximately 25% of PDAC patients, most notably in the DNA damage response and repair (DDR) genes, rendering cancer cells more sensitive to DNA-damaging...

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Identifiers

PMID: 31676541
DOI: 10.1158/1535-7163.MCT-19-0208
PMCID: PMC6830515

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