Article
Pneumococcal serotype determines growth and capsule size in human cerebrospinal fluid.
BMC microbiology - 20 Jan 2020
Müller Annelies, Salmen Anke, Aebi Suzanne, de Gouveia Linda, von Gottberg Anne, Hathaway Lucy J
Abstract excerpt
BACKGROUND: The polysaccharide capsule is a major virulence factor of S. pneumoniae in diseases such as meningitis. While some capsular serotypes are more often found in invasive disease, high case fatality rates are associated with those serotypes more commonly found in asymptomatic colonization. We tested whether growth patterns and capsule size in human cerebrospinal fluid depends on serotype using a clinical...
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