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Article

Diminished Capsule Exacerbates Virulence, Blood-Brain Barrier Penetration, Intracellular Persistence, and Antibiotic Evasion of Hyperhemolytic Group B Streptococci.

The Journal of infectious diseases - 13 Mar 2018

Gendrin Claire, Merillat Sean, Vornhagen Jay, Coleman Michelle, Armistead Blair, Ngo Lisa, Aggarwal Anjali, Quach Phoenicia, Berrigan Jacob, Rajagopal Lakshmi

Abstract excerpt

Group B streptococci (GBS) are encapsulated, β-hemolytic bacteria that are a common cause of infections in human newborns and certain adults. Two factors important for GBS virulence are the sialic acid capsular polysaccharide that promotes immune evasion and the hemolytic pigment that induces host cell cytotoxcity. These virulence factors are often oppositely regulated by the CovR/CovS two-component system....

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Identifiers

PMID: 29301010
DOI: 10.1093/infdis/jix684
PMCID: PMC5939829

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Source receipt: pubmed, retrieved 7 Sept 2026.

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