Article
Capsule type of Streptococcus pneumoniae determines growth phenotype.
PLoS pathogens - 1 Jan 2012
Hathaway Lucy J, Brugger Silvio D, Morand Brigitte, Bangert Mathieu, Rotzetter Jeannine U, Hauser Christoph, Graber Werner A, Gore Suzanna, Kadioglu Aras, Mühlemann Kathrin
Abstract excerpt
The polysaccharide capsule of Streptococcus pneumoniae defines over ninety serotypes, which differ in their carriage prevalence and invasiveness for poorly understood reasons. Recently, an inverse correlation between carriage prevalence and oligosaccharide structure of a given capsule has been described. Our previous work suggested a link between serotype and growth in vitro. Here we investigate whether capsule...
Topics
- Animals
- Animals, Outbred Strains
- Bacterial Capsules
- Bacterial Proteins
- Disease Models, Animal
- Female
- Gene Expression Regulation, Bacterial
- Mice
- Mutation
- Nasopharynx
- Phenotype
- Pneumococcal Infections
- Serotyping