Intra-serotype variation of Streptococcus pneumoniae capsule and its quantification

Abstract excerpt

ABSTRACT Streptococcus pneumoniae ( Spn ) is a leading respiratory pathogen that depends on a thick layer of capsular polysaccharide (CPS) to evade immune clearance. Disease prevention by CPS-based vaccines is limited because of the species’ high genome plasticity and ability to express over 100 different capsule types (serotypes). Generally, intra-serotype variations in capsulation are overlooked, despite the...

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