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Article

Adrenocortical cell and macrophage heterogeneity at single-cell spatial resolution in KCNJ5-mutant aldosterone-producing adenomas.

Endocrine-related cancer - 1 Feb 2026

He Furong, Hu Jinbo, Zeng Qinglian, Wang Xiao, Li Hongji, Li Ruolin, Li Jiayu, Li Junlong, Xiong Yunjie, Yin Juan, Liu Yunyan, Peng Chuan, Song Ying, Xu Yong, Huang Wei, Li Qifu, Ma Linqiang, Yang Shumin

Abstract excerpt

KCNJ5-mutant aldosterone-producing adenomas (APAs) represent a primary cause of primary aldosteronism, leading to severe secondary hypertension. However, the adrenal cellular heterogeneity and microenvironmental landscape of KCNJ5-mutant APAs remain to be characterized. Using single-cell RNA sequencing and spatial transcriptomics, we analyzed three paired KCNJ5-mutant APAs and distal adrenal tissues (DATs), with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41705625
DOI: 10.1530/ERC-25-0246

Genes

KCNJ5
CYP11B2
ITGAV
ITGB1
SPP1
TSPAN8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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