A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.

doi:10.1016/j.jhep.2019.12.019

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Article

A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.

Journal of hepatology - 1 May 2020

Namineni Sukumar, O'Connor Tracy, Faure-Dupuy Suzanne, Johansen Pål, Riedl Tobias, Liu Kaijing, Xu Haifeng, Singh Indrabahadur, Shinde Prashant, Li Fanghui, Pandyra Aleksandra, Sharma Piyush, Ringelhan Marc, Muschaweckh Andreas, Borst Katharina, Blank Patrick, Lampl Sandra, Neuhaus Katharina, Durantel David, Farhat Rayan, Weber Achim, Lenggenhager Daniela, Kündig Thomas M, Staeheli Peter, Protzer Ulrike, Wohlleber Dirk, Holzmann Bernhard, Binder Marco, Breuhahn Kai, Assmus Lisa Mareike, Nattermann Jacob, Abdullah Zeinab, Rolland Maude, Dejardin Emmanuel, Lang Philipp A, Lang Karl S, Karin Michael, Lucifora Julie, Kalinke Ulrich, Knolle Percy A, Heikenwalder Mathias

Abstract excerpt

BACKGROUND & AIMS: Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver-resident macrophages. However, hepatocytes, the parenchymal cells of the liver, also possess potent immunological functions in addition to their known metabolic functions. Owing to their abundance in the liver and known immunological functions, we aimed to investigate the direct antiviral...

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PMID: 31954207
DOI: 10.1016/j.jhep.2019.12.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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