Article
Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalisation.
Nature communications - 17 Jan 2020
Wragg D, Liu Q, Lin Z, Riggio V, Pugh C A, Beveridge A J, Brown H, Hume D A, Harris S E, Deary I J, Tenesa A, Prendergast J G D
Abstract excerpt
The extent to which the impact of regulatory genetic variants may depend on other factors, such as the expression levels of upstream transcription factors, remains poorly understood. Here we report a framework in which regulatory variants are first aggregated into sets, and using these as estimates of the total cis-genetic effects on a gene we model their non-additive interactions with the expression of other...
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