Article

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

2018-12-25

Abstract excerpt

<h4>ABSTRACT</h4> Despite high initial efficacy, therapies that target oncogenic kinases eventually fail in advanced, metastatic cancers. This failure in initially responsive tumors is the direct result of the evolution of drug resistance under therapy-imposed selective pressures. In contrast to the massive body of experimental research on the molecular mechanisms of resistance, understanding of its evolutionary...

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Literature Corpus work: 68047cac-05d3-5942-8ca7-b2448070063b
DOI: 10.1101/504837

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