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Article

Genetic variants in dopamine receptors influence on heterodimerization in the context of antipsychotic drug action.

Progress in molecular biology and translational science - 1 Jan 2020

Faron-Górecka Agata, Kuśmider Maciej, Solich Joanna, Górecki Andrzej, Dziedzicka-Wasylewska Marta

Abstract excerpt

Human dopamine D2 receptor (D2R) gene has polymorphic variants, three of them alter its amino acid sequence: Val96Ala, Pro310Ser and Ser311Cys. Their functional role never became the object of extensive studies, even though there are some evidence that they correlate with schizophrenia. The present work reviews data indicating that these mutations play a role in dimer formation with dopamine D1 receptor (D1R),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31952689
DOI: 10.1016/bs.pmbts.2019.11.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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