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Article

Combination of dopamine D2 receptor gene polymorphisms as a possible predictor of treatment-resistance to dopamine antagonists in schizophrenic patients.

Progress in neuro-psychopharmacology & biological psychiatry - 1 Sept 2003

Kondo Tsuyoshi, Mihara Kazuo, Suzuki Akihito, Yasui-Furukori Norio, Kaneko Sunao

Abstract excerpt

Both the A1 allele carriers of TaqI A and Del allele noncarriers of -141C Ins/Del for dopamine D(2) receptor (DRD(2)) gene polymorphisms have been reported to have a lowered DRD(2) density. The present study aimed to examine whether the combinations of these two DRD(2) gene polymorphisms predict treatment response to antidopaminergic agents in schizophrenic patients. Subjects consisted of 49 acutely exacerbated...

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Identifiers

PMID: 14499308
DOI: 10.1016/S0278-5846(03)00151-9

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