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Article

Genetic variants of dopamine D2 receptor impact heterodimerization with dopamine D1 receptor.

Pharmacological reports : PR - 1 Apr 2017

Błasiak Ewa, Łukasiewicz Sylwia, Szafran-Pilch Kinga, Dziedzicka-Wasylewska Marta

Abstract excerpt

BACKGROUND: The human dopamine D2 receptor gene has three polymorphic variants that alter its amino acid sequence: alanine substitution by valine in position 96 (V96A), proline substitution by serine in position 310 (P310S) and serine substitution by cysteine in position 311 (S311C). Their functional role has never been the object of extensive studies, even though there is some evidence that their occurrence...

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PMID: 28119185
DOI: 10.1016/j.pharep.2016.10.016

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