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Analysis of neuroleptic binding affinities and potencies for the different human D2 dopamine receptor missense variants

1 Feb 1999

Abstract excerpt

Neuroleptics, or antipsychotics, are widely used for the treatment of psychotic symptoms such as hallucinations and delusions in schizophrenia and other psychiatric disorders. Pharmacotherapy of these diseases is frequently complicated by a great variability in the clinical response to neuroleptics and by the development of serious and potentially life-threatening side-effects. Brain D2 dopamine receptors are one...

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PMID: 10208638
DOI: 10.1097/00008571-199902000-00003

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