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Article

Antioxidant supplementation partially rescues accelerated ovarian follicle loss, but not oocyte quality, of glutathione-deficient mice†.

Biology of reproduction - 24 Apr 2020

Lim Jinhwan, Ali Samiha, Liao Lisa S, Nguyen Emily S, Ortiz Laura, Reshel Samantha, Luderer Ulrike

Abstract excerpt

The tripeptide thiol antioxidant glutathione (GSH) has multiple physiological functions. Female mice lacking the modifier subunit of glutamate cysteine ligase (GCLM), the rate-limiting enzyme in GSH synthesis, have decreased GSH concentrations, ovarian oxidative stress, preimplantation embryonic mortality, and accelerated age-related decline in ovarian follicles. We hypothesized that supplementation with thiol...

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Identifiers

PMID: 31950131
DOI: 10.1093/biolre/ioaa009
PMCID: PMC7186779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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