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Article

Prevention of age-related truncation of γ-glutamylcysteine ligase catalytic subunit (GCLC) delays cataract formation.

Science advances - 26 Apr 2024

Wei Zongbo, Hao Caili, Radeen Kazi Rafsan, Srinivasagan Ramkumar, Chen Jian-Kang, Sharma Shruti, McGee-Lawrence Meghan E, Hamrick Mark W, Monnier Vincent M, Fan Xingjun

Abstract excerpt

A sharp drop in lenticular glutathione (GSH) plays a pivotal role in age-related cataract (ARC) formation. Despite recognizing GSH's importance in lens defense for decades, its decline with age remains puzzling. Our recent study revealed an age-related truncation affecting the essential GSH biosynthesis enzyme, the γ-glutamylcysteine ligase catalytic subunit (GCLC), at aspartate residue 499. Intriguingly, these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38669339
DOI: 10.1126/sciadv.adl1088
PMCID: PMC11051666

Genes

GCLC
ARC
GCLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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