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Alterations in oocyte mitochondrial number and function are related to spindle defects and occur with maternal aging in mice and humans†

24 Nov 2018

Abstract excerpt

The objective of this work was to determine the role of mitochondria in the loss of oocyte quality with maternal aging. Our results show that mitochondrial DNA (mtDNA) copy number and function are reduced in eggs from aged mice after both in vivo and in vitro maturation. Higher incidences of spindle abnormalities were observed in old eggs. However, no correlation with egg ATP content was found. In vitro matured...

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PMID: 30476005
DOI: 10.1093/biolre/ioy248

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