Article
Proteomic Analysis of the Senescence-Associated Secretory Phenotype: GDF-15, IGFBP-2, and Cystatin-C Are Associated With Multiple Aging Traits.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Mar 2024
Evans Daniel S, Young Danielle, Tanaka Toshiko, Basisty Nathan, Bandinelli Stefania, Ferrucci Luigi, Campisi Judith, Schilling Birgit
Abstract excerpt
Cellular senescence, a hallmark of aging, results in a senescence-associated secretory phenotype (SASP) with an increased production of proinflammatory cytokines, growth factors, and proteases. Evidence from nonhuman models demonstrates that SASP contributes to tissue dysfunction and pathological effects of aging. However, there are relatively few human studies on the relationship between SASP and aging-related...
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