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Article

Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase.

Cardiovascular research - 1 Oct 2014

Werfel Stanislas, Jungmann Andreas, Lehmann Lorenz, Ksienzyk Jan, Bekeredjian Raffi, Kaya Ziya, Leuchs Barbara, Nordheim Alfred, Backs Johannes, Engelhardt Stefan, Katus Hugo A, Müller Oliver J

Abstract excerpt

AIMS: Inducible gene targeting in mice using the Cre/LoxP system has become a valuable tool to analyse the roles of specific genes in the adult heart. However, the commonly used Myh6-MerCreMer system requires time-consuming breeding schedules and is potentially associated with cardiac side effects, which may result in transient cardiac dysfunction. The aim of our study was to establish a rapid and simple system...

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PMID: 25082846
DOI: 10.1093/cvr/cvu174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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