The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis.

Abstract excerpt

The link between mutations associated with intellectual disability (ID) and the mechanisms underlying cognitive dysfunctions remains largely unknown. Here, we focused on PAK3, a serine/threonine kinase whose gene mutations cause X-linked ID. We generated a new mutant mouse model bearing the missense R67C mutation of the Pak3 gene (Pak3-R67C), known to cause moderate to severe ID in humans without other clinical...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cognitive Dysfunction
• Share to Disease Models, Animal