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Article

PAK in Alzheimer disease, Huntington disease and X-linked mental retardation

1 Apr 2012

Abstract excerpt

Developmental cognitive deficits including X-linked mental retardation (XLMR) can be caused by mutations in P21-activated kinase 3 (PAK3) that disrupt actin dynamics in dendritic spines. Neurodegenerative diseases such as Alzheimer disease (AD), where both PAK1 and PAK3 are dysregulated, may share final common pathways with XLMR. Independent of familial mutation, cognitive deficits emerging with aging, notably...

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PMID: 23162743
DOI: 10.4161/cl.21602

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