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Article

The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway.

The Journal of biological chemistry - 20 Jul 2007

Kreis Patricia, Thévenot Emmanuel, Rousseau Véronique, Boda Bernadett, Muller Dominique, Barnier Jean-Vianney

Abstract excerpt

The p21-activated kinase 3 (PAK3) is one of the recently identified genes for which mutations lead to nonsyndromic mental retardation. PAK3 is implicated in dendritic spine morphogenesis and is a key regulator of synaptic functions. However, the underlying roles of PAK3 in these processes remain poorly understood. We report here that the three mutations R419X, A365E, and R67C, responsible for mental retardation...

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Identifiers

PMID: 17537723
DOI: 10.1074/jbc.M703298200

Genes

PAK3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway.PMID 17537723Read ↗

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Sequential implication of the mental retardation proteins ARHGEF6 and PAK3 in spine morphogenesis.Semantic proximity Read ↗

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A mutation in PAK3 with a dual molecular effect deregulates the RAS/MAPK pathway and drives an X-linked syndromic phenotype.Semantic proximity Read ↗

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PAK3 mutation in nonsyndromic X-linked mental retardation.Semantic proximity Read ↗

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