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Article

The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway.

The Journal of biological chemistry - 20 Jul 2007

Kreis Patricia, Thévenot Emmanuel, Rousseau Véronique, Boda Bernadett, Muller Dominique, Barnier Jean-Vianney

Abstract excerpt

The p21-activated kinase 3 (PAK3) is one of the recently identified genes for which mutations lead to nonsyndromic mental retardation. PAK3 is implicated in dendritic spine morphogenesis and is a key regulator of synaptic functions. However, the underlying roles of PAK3 in these processes remain...

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Source

Identifiers

PMID: 17537723
DOI: 10.1074/jbc.M703298200

Genes

PAK3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17537723-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway.PMID 17537723Read ↗

PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration.Semantic proximity Read ↗

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Sequential implication of the mental retardation proteins ARHGEF6 and PAK3 in spine morphogenesis.Semantic proximity Read ↗

The p21-activated kinases in neural cytoskeletal remodeling and related neurological disordersSemantic proximity Read ↗

A mutation in PAK3 with a dual molecular effect deregulates the RAS/MAPK pathway and drives an X-linked syndromic phenotype.Semantic proximity Read ↗

A de novo mutation in the X-linked PAK3 gene is the underlying cause of intellectual disability and macrocephaly in monozygotic twins.Semantic proximity Read ↗

PAK3 mutation in nonsyndromic X-linked mental retardation.Semantic proximity Read ↗

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