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Article

The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity.

The Journal of biological chemistry - 31 Aug 2012

Combeau Gaëlle, Kreis Patricia, Domenichini Florence, Amar Muriel, Fossier Philippe, Rousseau Véronique, Barnier Jean-Vianney

Abstract excerpt

p21-activated kinase 1 (PAK1) and PAK3 belong to group I of the PAK family and control cell movement and division. They also regulate dendritic spine formation and maturation in the brain, and play a role in synaptic transmission and synaptic plasticity. PAK3, in particular, is known for its implication in X-linked intellectual disability. The pak3 gene is expressed in neurons as a GTPase-regulated PAK3a protein...

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Source

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Identifiers

PMID: 22815483
DOI: 10.1074/jbc.M112.355073
PMCID: PMC3436265

Genes

PAK1
PAK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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