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Article

Mast cell and monocyte recruitment by S100A12 and its hinge domain.

The Journal of biological chemistry - 9 May 2008

Yan Wei Xing, Armishaw Chris, Goyette Jesse, Yang Zheng, Cai Hong, Alewood Paul, Geczy Carolyn L

Abstract excerpt

S100A12 is expressed at sites of acute, chronic, and allergic inflammation. S100 proteins have regions of high sequence homology, but the "hinge" region between the conserved calcium binding domains is structurally and functionally divergent. Because the murine S100A8 hinge domain (mS100A8(42-55)) is a monocyte chemoattractant whereas the human sequence (hS100A8(43-56)) is inactive, we postulated that common...

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PMID: 18292089
DOI: 10.1074/jbc.M710388200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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