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Article

Polycystin-2 is regulated by endoplasmic reticulum-associated degradation.

Human molecular genetics - 15 Apr 2008

Liang Genqing, Li Qiang, Tang Yan, Kokame Koichi, Kikuchi Tadashi, Wu Guanqing, Chen Xing-Zhen

Abstract excerpt

Endoplasmic reticulum(ER)-associated degradation (ERAD) is an essential process for cell homeostasis and remains not well understood. During ERAD, misfolded proteins are recognized, ubiquitinated on ER and subsequently retro-translocated/dislocated from ER to the 26S proteasome in the cytosol for proteolytic elimination. Polycystin-2 (PC2), a member of the transient receptor potential superfamily of cation...

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PMID: 18178578
DOI: 10.1093/hmg/ddm383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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