Article
Bleomycin-induced pulmonary fibrosis susceptibility genes in AcB/BcA recombinant congenic mice.
Physiological genomics - 21 Sept 2005
Lemay Anne-Marie, Haston Christina K
Abstract excerpt
The genetic basis of susceptibility to pulmonary fibrosis is largely unknown. Initially, in this study, loci regulating the response of bleomycin-induced pulmonary fibrosis were mapped using a set of recombinant congenic strains bred from pulmonary fibrosis-resistant A/J and susceptible C57BL/6J (B6) mice. Linkage was identified (logarithm of the odds score = 4.9) on chromosome 9, and other suggestive loci were...
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