Article
DDR1 autophosphorylation is a result of aggregation into dense clusters.
Scientific reports - 19 Nov 2019
Corcoran David S, Juskaite Victoria, Xu Yuewei, Görlitz Frederik, Alexandrov Yuriy, Dunsby Christopher, French Paul M W, Leitinger Birgit
Abstract excerpt
The collagen receptor DDR1 is a receptor tyrosine kinase that promotes progression of a wide range of human disorders. Little is known about how ligand binding triggers DDR1 kinase activity. We previously reported that collagen induces DDR1 activation through lateral dimer association and phosphorylation between dimers, a process that requires specific transmembrane association. Here we demonstrate ligand-induced...
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