Article
Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function.
Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2007
Chattopadhyay Kausik, Ramagopal Udupi A, Mukhopadhaya Arunika, Malashkevich Vladimir N, Dilorenzo Teresa P, Brenowitz Michael, Nathenson Stanley G, Almo Steven C
Abstract excerpt
Glucocorticoid-induced TNF receptor ligand (GITRL), a recently identified member of the TNF family, binds to its receptor GITR on both effector and regulatory T cells and generates positive costimulatory signals implicated in a wide range of T cell functions. Structural analysis reveals that the human GITRL (hGITRL) ectodomain self-assembles into an atypical expanded homotrimer with sparse monomer-monomer...
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