Article

Human to yeast pathway transplantation: cross-species dissection of the adenine de novo pathway regulatory node

2017-06-14

Abstract excerpt

Pathway transplantation from one organism to another represents a means to a more complete understanding of a biochemical or regulatory process. The purine biosynthesis pathway, a core metabolic function, was transplanted from human to yeast. We replaced the entire Saccharomyces cerevisiae adenine de novo pathway with the cognate human pathway components. A yeast strain was “humanized” for the full pathway by del...

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Literature Corpus work: ad2198d5-708c-508d-9b06-4d46ec5c9aa9
DOI: 10.1101/147579

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