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Article

Estrogen receptor alpha isoform ERdelta7 in myometrium modulates uterine quiescence during pregnancy

28 Nov 2018

Abstract excerpt

BACKGROUND: Circulating estrogen (E2) levels are high throughout pregnancy and increase towards term, however its local tissue specific actions vary across gestation. For example, myometrial E2 regulated uterotonic action is disabled until term, whereas it's proliferative function is maintained in the breast. We have identified gestationally regulated splicing events, mediated by hnRNPG and modulated by E2 that...

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PMID: 30502052
DOI: 10.1016/j.ebiom.2018.11.038

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