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Regioselective Chemical Modification of Cysteine Residues on Protein Surfaces Focusing on Local Environment around the Conjugation Site.

Bioconjugate chemistry - 18 Mar 2020

Miyake Teruyuki, Tamaki Ryosei, Asanuma Moeko, Fukada Yoji, Hirota Shun, Matsuo Takashi

Abstract excerpt

For chemical modification of cysteines in a protein, the regioselectivity among cysteine residues on the protein surface is an issue to be considered. To elucidate the determinants of cysteine reactivities on protein surfaces, we have investigated the chemical modification of the adenylate kinase A55C/C77S/V169C mutant as an experimental model. Although Cys55 and Cys169 are commonly located on the protein...

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PMID: 31935079
DOI: 10.1021/acs.bioconjchem.9b00869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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